The membrane proteins have crucial roles in physiological processes because they provide and control the majority of communications between cells. They are also involved in a large number of disorders and in resistance to antibiotics and anticancer-drugs, and are therefore major pharmaceutical targets.
To elucidate the molecular mechanisms governing the functions and dysfunctions of these proteins and to rationally develop new drugs targeting them, it is necessary to apply an integrated approach based on structural, functional and dynamic analysis of these proteins. However, the location of these proteins in a lipid bilayer generates experimental complications. To overcome these obstacles, new methods have been developed with success.
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