Job offers

Job offers

You can find here job offers proposed by GDR members or partners.

Post-doctoral position in INSERM ERL1226 Toulouse in Nanotherapy targeted for cancer

on 26 June 2017

Post-doctoral position in Toulouse in Nanotherapy targeted for cancer

 

A post-doctoral position is now opened in the INSERM ERL1226 Team of Receptology and Therapeutic Targeting in Cancerology of the Laboratory of Physics and Chemistry of Nano-Objects (LPCNO-CNRS UMR5215-INSA), in Toulouse. This position is funded by the Labex NEXT.

Scientific context: Endocrine tumors are usually diagnosed by an imaging technique using a radio-labeled peptide (somatostatin or Osteoscan), the receptor of which is present in 80% of the tumors. Overexpression of the CCK2R cholecystokinin receptor belonging to the transmembrane domain (R7TM) family has also been demonstrated in a collection of human endocrine tumors. Moreover, the studies carried out in our team show that this receptor is massively internalized and is directed with its ligand towards the lysosomes.

Our team established in vitro proof of concept that overexpression of CCK2R in endocrine tumors compared to healthy tissues and its capacity for massive internalization could be used to develop a new therapeutic approach. This strategy is based on the use of magnetic nanoparticles functionalized with the CCK2R selective agonist, gastrin. Our results show that the nanoparticles thus vectorized are massively and specifically internalized in cancer cells expressing the CCK2R, and then accumulated in the lysosomes, according to a mechanism identical to the free ligand. The application of an alternating magnetic field induces the death of 25 to 50% of the tumor cells, depending on the cell model. We have called this mechanism: magnetic intra-lysosomal hyperthermia because it occurs without detectable temperature increase. Recent results show that this new approach activates a particular death pathway that could be an alternative to cancer treatments, especially on resistant cancer cells.

Objectives of the project: The project developed by the candidate will be integrated into the research axis "Targeted nanotherapy of cancers by magnetic intra-lysosomal hyperthermia". The objectives will consist, on one hand, in continuing the study of the mechanisms involved in the death of cancer cells and, on the other hand, in increasing the effectiveness of this strategy by optimizing several parameters Heating of nanoparticles, use of pharmacological agents, etc.). In vivo studies may also be considered on the murine transgenic MEN1 knockout model representative of human MEN1 syndrome, developing multiple endocrine tumors. The efficacy of therapeutic targeting and the magnetic intra-lysosomal hyperthermia nanotherapy to inhibit tumor growth or induce tumor regression will be evaluated.

Profile: We are looking for a candidate with a PhD in life sciences and a strong background and expertise in cellular biology and/or physiology. He (She) must possess:

  • Knowledge in: cell biology, physiology and pathophysiology applied to cancer, pharmacology, receptors.
  • Expertise in: animal experiments, cell culture, histology, immunohistochemistry, microscopy, flow cytometry, transfection.
  • Abilities: good communication in the context of teamwork, coaching of students

Administrative aspects: The post-doctoral position is funded for 12 months. The position will be open in September 2017. The post-doctoral position may be extended depending on the acceptance of additional funding requests.

Applicants should submit curriculum vitae, a list of publications, a brief description of their research and the career goals to Véronique GIGOUX (This email address is being protected from spambots. You need JavaScript enabled to view it.) or Daniel FOURMY (This email address is being protected from spambots. You need JavaScript enabled to view it.) .

www.rttc-research.com

stdoctoral position at UMR242 of University of Strasbourg

on 26 June 2017

A postdoctoral position is available in the UMR242 of University of Strasbourg in the group “GPCR&cardiobiology”. In the course of an ERA-NET, ERA-CVD project aiming to develop new therapeutic strategy against cardiotoxicity induced by anticancer agents, the candidate will be in charge on the elaboration and evaluation of the novel cardio-protective therapeutics in human stem cell-based in vitro models and in in vivo mouse models. He/She will. He/She will also be involved in the identification of the molecular pathways involved in anticancer drug-induced HF. The candidate must have an interdisciplinary background in molecular and cell biology.

Due to the highly pluridisciplinary project, the successful candidate should hold a PhD in molecular & cellular biology, or chemical-biology and must have a high-quality expertise in standard biochemical &cellular assays. She will learn animal experimentation during her post-doctoral training.

A contract of one year and financed by the French research agency is available starting June 1st 2017. Motivated candidate should contact Dr. Canan NEBIGIL-Désaubry (This email address is being protected from spambots. You need JavaScript enabled to view it.) and provide a short justification of his/her interest in the project/position and a CV with accompanying two recommendation letters.

Postdoctoral Associate position in University of Pittsburgh (USA)

on 10 November 2016

School/Departments:

 University of Pittsburgh, School of Medicine / Psychiatry and Cell Biology

 

Position:

Postdoctoral Associate

 

Description: A postdoctoral position is available immediately to study dopamine signaling in pancreatic metabolic regulation in the Freyberg laboratory located within the Departments of Psychiatry and Cell Biology.

Attachments:
Download this file (Freyberg postdoctoral ad.pdf)Freyberg postdoctoral ad.pdf[ ]332 kB

Post-Doctoral Fellowship: Olfactory receptor-based biosensors

on 25 September 2016

Job offer preview

Post-Doctoral Fellowship: Olfactory receptor-based biosensors

Design and optimization of biosensors based on olfactory receptors linked to an ion channel for integration in nanoelectronic platforms

Attachments:
Download this file (ERC_PostDoc_2016.pdf)ERC_PostDoc_2016.pdf[ ]152 kB

PostDoc offer: Receptor signaling and Molecular Scaffolds, Institut Cochin, Paris

on 08 June 2016

Please download the attached pdf file for more information.

Attachments:
Download this file (PostDoc Position opened.pdf)PostDoc Position opened.pdf[ ]39 kB