Subject. G Protein-Coupled Receptors (GPCRs) are membrane proteins involved in the communication between cells through circulating messengers (hormones, neurotransmitters) and also in sensing our environment (vision, smell, taste). They are essential to numerous physiological functions which are vital (cardiac, breathing,...) and behavioral (social and emotional relationships). We have developed an original biosensor based on the attachment of GPCRs to an ion channel and referred to Ion Channel-Coupled Receptors (ICCRs) (Moreau et al. Nature Nanotechnology 2008). Motions of the receptor induced by its activity (ligand binding, G protein activation) are translated by the ion channel into an electric current easily detectable by electrophysiological techniques. In the frame of a project funded by the European Research Council (ERC), the PhD student will develop this technology in collaboration with partners from the Seoul National University in order to design original biosensors in interface with nanoelectronic systems.
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