University of Birmingham
College of Medical and Dental Sciences
Institute of Metabolism and Systems Research
Post Title: Research Fellow – Research Fellow (Postdoc) on single-molecule pharmacology of G protein-coupled receptors – 80206
Duration: Full Time, Fixed Term for 3 years
Salary: 7, Full time starting salary is normally in the range £30,395 to £39,609. With potential progression once in post to £42,036 a year.
Location: University of Birmingham, Edgbaston, Birmingham, UK
Summary of Role
Our group investigates the molecular mechanisms of signalling by G protein-coupled receptors (GPCRs), which mediate the effects of many hormones and neurotransmitters and are major drug targets. To this end, we develop innovative biophysical methods based on single-molecule microscopy and FRET (e.g. Calebiro et al. PNAS 2013; Godbole et al. Nat. Commun. 2017; Sungkaworn et al. Nature 2017). The successful applicant will utilize and further develop innovative biophysical methods based on single-molecule microscopy and advanced computational algorithms to analyse the composition and dynamics of receptor signalling nanodomains in living cells. This approach will be used to clarify some of the most crucial mechanisms involved in adrenergic receptor signalling in cardiomyocytes under normal and pathological conditions, with the ultimate goal of developing novel therapeutic strategies for cardiovascular and endocrine diseases. The project will involve designing and carrying out single-molecule microscopy experiments in living cells as well as with purified proteins to investigate the dynamic interactions among receptors, G proteins and beta-arrestins that are at the basis of GPCR signalling.
Key Responsibilities Involved
• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Disseminate research findings for publication, research seminars, etc.
• Contribute to developing new models, techniques and methods
• Contribute to Departmental/School research-related activities
• Collect research data
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines
• Completed or about to complete a PhD in biophysics, receptor pharmacology or related area
• Solid background in single-molecule imaging or similar advanced microscopy methods
• Ideally, previous experience with image analysis (e.g. single-particle tracking), programming and/or the design of optical setups
• Enthusiasm for interdisciplinary experimental research
Closing Date: 19/11/2018
To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from www.hr.bham.ac.uk
Valuing excellence; sustaining investment
Postdoctoral position, two years (start Oct.2018)
IRIBHM institute, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels
Our group is interested in stem cells of the digestive tract and their role in development, homeostasis and regeneration. It is one of the units of the multidisciplinary research institute IRIBHM engaged in a variety of projects dealing with developmental, cell and molecular biology, genetics, biochemistry, bioinformatics, and neuroscience.
We are seeking a highly motivated postdoctoral candidate to join our group. The research project is focused on the intestinal and gastric epithelia, which are amongst the epithelia with highest self-renewing capacity in adult mammals and therefore represent an excellent model system to study stem cell biology. The aim of the project is to dissect the molecular mechanisms associated with the biological function of the adult stem cell markers Leucine-rich repeat-containing G-protein coupled receptors (Lgr4/ Lgr5) in the context of tumor development. This will be addressed by combination of studies using in vivo mouse models and the ex vivo three-dimensional culture system.
We are looking for PhD-holder candidates with significant theoretical and practical background in molecular and cell biology, genetics and biochemistry. Experience in the GPCR field and/or in oncological mouse models would be an advantage. The candidate should have excellent independent organizational skill as well as strong collaborative abilities. A good level of written and spoken English is mandatory.
For more information please visit: https://iribhm.org/isabelle-garcia-gilbert-vassart/
Although not required, selected candidates will be highly encouraged to apply for (inter)national funding. In this context, candidates should have at least one first author paper in a peer-reviewed journal.
Application should contain the following items:
iii) contact information for three references
Post-doctoral positions are available at the Laboratory for GPCR BiologyDepartment of Pharmacology & Chemical BiologyUniversity of Pittsburgh, School of Medicine
The Laboratory for GPCR Biology located at the Department of Pharmacology & Chemical Biology and funded by the NIH is seeking two candidates for post-doctoral fellowship positions to determine signaling mechanisms underlying the function of PTH-receptor and other GPCRs at theatomic/molecular level using Protein Biochemistry, Mass Spectrometry, X-ray Crystallography, NMR and/or Single Molecule approaches (position #1), and cellular level using TIRF/confocal/epifluorescence microscopy (position #2). The information obtained through this research will advance the development of new therapeutics for bone and mineral diseases, including medications for osteoporosis and hypocalcemia.
Preference will be given to PhD or MD/PhD applicants with a solid experience in Biochemistry, Structural Biology or Cell Biology using FRET/BRET, and with at least 2 first-authored articles published in international journals.
The University of Pittsburgh is an Equal Opportunity/Affirmative Action Employers with strong institutional commitments to diversity. Women and minority candidates are particularly encouraged to apply.
Post-doctoral position in molecular modeling
Institute for research in immunology and cancer
Medicinal chemistry core facility
Salary: To be determined – Subject to the minimum and maximum set out by the collective agreement
Start date: Spring 2018
Estimated end date: 1 year, renewable
The medicinal chemistry platform at the Institute for Research in Immunology and Cancer (IRIC) at the University of Montréal has an opening for a postdoctoral position in molecular modeling in the field of drug discovery.
Under the supervision of Dr. Anne Marinier and Dr. Alexandre Beautrait, the incumbent will conduct computer-aided modeling work that support ongoing projects across various therapeutic areas (academic and industrial collaborations). As part of a multi-disciplinary team of medicinal chemists and biologists the incumbent will apply computational chemistry techniques (both ligand and structure-based) to support lead-identification and lead-optimization endeavors taking place at the medicinal chemistry platform.
Postdoctoral position in “GPCR cell surface architecture”
Toulouse, I2MC, France
A 31 months post-doctoral position (ANR french funding “GRApHICS”) is available for a highly motivated post-doc fellow to join a research group specialized in the pharmacology of G Protein Coupled Receptor (GPCR) to study the cell surface organization of these receptors in living cells using AFM-single molecule force spectroscopy.
For more information see attached file