ACEA Biosciences, Inc. has been a pioneer in the development and commercialization of high-performance microelectronic systems for cell-based assays. ACEA has a product line of 6 systems with different functionalities and throughputs, which are commercialized globally under the xCELLigence® and iCELLigenceTM brand. ACEA was founded in 2002, is headquartered in San Diego, CA, USA and has its state-of-the-art manufacturing plant in Hangzhou, China, which is ISO9001 certified. (www.aceabio.com)
The core of the technology is the biosensor integrated into the bottom of 16 and 96-well micro titer plates which provide quantitative information about the biological status of attached cells: any changes to cell number, size, and morphology or attachment quality will be detected in real-time without the use of reporter reagents.
This innovative biosensor technology for label-free, real-time cell-analysis (RTCA) has a variety of applications in drug development, toxicology, cancer research, and medical microbiology and virology:
The integrated RTCA software allows data to be collected and saved automatically as often as every ten seconds over virtually any time period during the experiment.
More than 800 xCELLigence systems were installed in the world, more than 400 in Europe. The publication of over 400 peer-reviewed scientific papers citing the technology is a testament to the integration of the xCELLigence system as part of routine cell analysis and drug discovery workflow. In France, 36 systems were installed in Pharmaceutical companies, Research Units or Platforms, as in the “Institute Cochin”, one of our reference users for the technology.