G protein-coupled receptors (GPCR) represent the largest family of proteins expressed at the cell surface. GPCRs are involved in multiple physiological and pathological processes, and are targeted by 30-40% of currently prescribed drugs. Regardless of this fact, these drugs target only 10% of all GPCRs highlighting the great potential of this protein family for future drug design.
GPCR research is multi-disciplinary, dealing with numerous biological and pathological processes. Accordingly, GPCR researchers often work in different fields and research organizations. The primary aim of the GDR3545 was to gather the different players working in this field in France.
The GDR has the following 4 specific objectives: