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Events of the GDR 3545

You can find here all events related to the GDR. For some of these, if you want to participate, you will have to fill a register form at the bottom of the description.

GDR3545 statellite meeting Sao Paolo

on 18 April 2019

A GDR-3545 Satellite Meeting just took place in Brazil. Co-organized by the University of Sao Paulo (USP) (Brazil) (Dr. Celia Garcia) and the GDR-3545 (Dr. Ralf Jockers), the satellite meeting was held from March 18th to 22nd 2019 at the USP campus in Sao Paulo. During 1 week, the attendees had the opportunity to listen and to discuss with local and international speakers about the State-of-the-Art on GPCRs, drug discovery and innovation. Attendees presented their own work in the poster session or in selected short-talks. Among the speakers there were 10 GDR members, Dr. Michel Bouvier (Canada), and more than 20 local researchers and agents from pharmaceutical companies, start-ups, funding agencies and agencies supporting innovation and entrepreneurship. The meeting had 80 registered attendees, comprising researchers from public and private institutions, as well as undergraduate students, as the event was registered as a discipline of the Pharmaceutical School of USP for PhD and Master students. The meeting provided a favorable environment for scientific exchanges, and also for the establishment of new collaborations or strenghtening of already existent ones.

Upcoming GDR3545-USP Satellite Meeting on GPCR Signaling and Drug discovery

on 15 March 2019

A GDR-3545 Satellite Meeting, co-organized by the University of Sao Paulo (USP) (Brazil) (Dr. Celia Garcia) and the GDR-3545 (Dr. Ralf Jockers), will be held from March 18th to 22nd 2019 at the USP campus in Sao Paulo. The meeting is expected to bring together local and international researchers to discuss the State-of-the-Art on GPCRs, drug discovery and innovation. Among the confirmed speakers are 10 GDR members, Dr. Michel Bouvier (Canada), more than 20 local researchers and agents from pharmaceutical companies, start-ups, funding agencies and agencies supporting innovation and entrepreneurship. The meeting is expected to have approximately 100 attendees, comprising researchers from public and private institutions, as well as undergraduate students, as it is registered as a discipline of the Pharmaceutical School of USP for PhD and Masters students.

For more information please access the website of the event:

Download this file (WEBSITE Program-2019.pdf)GDR3545-USP satelite meeting program[ ]3015 kB

7th Annual Meeting of GDR3545, GPCR-Physio-Med in Strasbourg

on 23 April 2018
7th annual meeting of GDR3545 about GPCRs will take place in Strasbourg, october 29 - 31th, 2018
GPCR meeting in Strasbourg, october 2018

Download the preliminary programme : Programme of the 7th Annual Meeting of GDR3545

Deadline for abstract submission and registration : September 25th, 2018 

Venue and Access : Link

Scientific programme

6th GDR3545 workshop for Young researchers sponsored by the Dr. Antoni Esteve Foundation  October 28th (afternoon) to 29th (morning):  
Drug discovery of GPCR : scientific and career points of view in biotech and academia

Monday, October 29th 2018

12h00            Registration

14:15             Opening

Session 1: GPCRs and biased signalling

Chairs : Dominique Bonnet and Jean-Luc Galzi

14:30             Kjell Fuxe (Karolinska Institute, Sweden)
Allosteric receptor-receptor interactions in GPCR heteroreceptor complexes alter receptor protomer function. Focus on A2AR-D2R heteroreceptor complexes and cocaine addiction

15:20             Luc Maroteaux (Institut du Fer à Moulin, Paris, France)
Dimers among serotonin receptors: impact on ligand affinity and signaling

15:45             Franck Vandermoere (IGF, Montpellier, France)
Crosstalk by phospohorylation between 5HT2A and mGlU2 receptors, two important targets for antipsychotics

16:10             Alan Hégron (Institut Cochin, Paris, France) 
Identification of key regions mediating human melatonin MT1 receptor biased signaling revealed by natural variants

16:25             Francesco De Pascali (INRA, Nouzilly, France)
Biasing FSHR signaling by low molecular weight allosteric ligands

16: 40           Industrial sponsors pitches session

16:55            Coffee break

17:30            Stephan Schann (Domain Therapeutics, Illkirch, France)
Discovery of Foliglurax, an mGluR4 PAM for the Treatment of Parkinson’s Disease

18:20             Véronique Pons (I2MC, Toulouse, France)
P2Y12 receptor constitutive activity as a new target for antiplatelt therapy

18:45             Kleouforo Paul Dembele (IRIB, Rouen, France)
Analysis of G protein expression level and functions in glioma development

19:00             Thibaut Laboute (INRA, Nouzilly, France)
The orphan GPR88 receptor biases opioid receptors and other GPCR signaling through sequestration of b-arrestin

19:15             Jianfeng Liu (Huazhong University, Wuhan, Hubei, China)
GABA receptor signaling and Aging

19:30             Flash posters session 1


                        Xiaojing Cong (Université Côte d’Azur , Nice, France)
P05: Mechanism of GPCR activation triggered by ligands, mutations and protonation

                        Daniele Di Marino (Università della Svizzera Italiana, Lugano, Switzerland)
P09: A Comprehensive Description of the Homo and Heterodimerization Mechanism of the Chemokine Receptors CCR5 and CXCR4

                        Fabien Hanser (Université de Strasbourg, France)
P17: Non-Peptidic Fluorescent Turn-on Probes for Live-Cell Imaging of GPCRs

Marie-Lise Jobin (University of Würzburg, Germany)
P23: Spatial organization and dynamics of GABAB receptors as revealed by single-molecule microscopy

Kerstin Seier (University of Würzburg, Germany)
P39: Investigation of mu opioid receptor dimerization with new fluorescent ligands


19:45             Poster session (odd numbers) & Buffet


Tuesday, October 30th 2018

Session 2: GPCRs and dynamics

Chair : Didier Rognan

9:00               Laura Heitman (Leiden University, Netherlands)
Drug-target binding kinetics – a case for GPCRs

9:45               Nicolas Floquet (IBMM, Montpellier, France)
Coarse-grained simulations to predict the dynamical interactions of GPCRs with their favorite partners at the molecular level

10:15             Industrial sponsors pitches session

10:30             Coffee break

11:00             Vladimir Katanaev (University of Lausanne, Switzerland)
High capacity in G protein-coupled receptor signaling: application of information theory to signaling in health and disease

11:45             Marie Chabbert (Laboratoire MITOVASC, Angers, France)
Mutations in the sodium binding site played a key role in the evolution of chemokines receptors

12:10             Patricia Pacios Centeno (University of Manchester, UK)
Phosphate sensed by the Calcium-Sensing Receptor and its contribution to the Secondary Hyperparathyroidism of Chronic Kidney Disease

12:25             Photo & Lunch

Session 3: GPCRs, compartmentalization & signalling

Chairs : Dominique Massotte and Katia Befort

14:30             Davide Calebiro (University of Birmingham/University of Würzburg)
Shedding new light on the nanoscale organization of GPCR signalling

15:20             Guillaume Lebon (IGF, Montpellier, France)
Structural and molecular basis of Class C GCPR signalling

15:45            Claudia Desole (Université Paris Descartes, Paris, France)
Design, synthesis, pharmacological evaluation and molecular modeling of new potential antagonists targeting group III mGluRs

16:00             Alexandre Mutel (IRIB, Rouen, France)
GPCR’s activity is controlled by Filamin A in glioblastoma

16:15             Coffee break

17:00             Mario Mellado (National Center for Biotechnology, Madrid)
Modulating chemokine receptor clustering, signaling and cell responses

17:50             Anne Brelot (Institut Pasteur, Paris, France)
CCR5 adopts three homodimeric conformations that control cell surface delivery

18:15             Stefano Marullo (Institut Cochin, Paris, France)
Sialic acid-mediated mechanical activation of β2-adrenergic receptors by bacterial pilins

18:40             Lucie Hartmann (IMPReSs platform, Strasbourg, France)
Production of Antibodies Against Model G Protein Coupled Receptors Using Recombinant Semliki Forest Virus Particles as Immunogens

18:55             19:30      Flash posters session 2


                        Chayma El Khamlichi (Université d’Orléans, Orléans, France)
P10: Identification of biased ligands of 5-HT7 receptor: Molecular bases of their action

Nicolas Kahale (Université Paris Sud, Paris, France)
P18: TGR5-mediated signaling in the regulation of biliary epithelium permeability

                        Sridevi M Ramanoudjame (Université de Strasbourg, France)
P24: Fluorocarbon-peptide conjugates (FPC): new concept to increase the metabolic stability of peptides for therapeutic applications.

Steve Reynaud (Université Paris Sud, Paris, France)
P26: The first animal toxins targeting MC4R, a GPCR that controls your hunger

Maria Ricart-Ortega (IGF, Montpellier, France)
P30: Evaluating the influence of applied light on trans and cis alloswitch-1 binding to the metabotropic glutamate receptor mGlu5

19:10             General assembly animated by Ralf Jockers

19:40             Poster session (even numbers) & Gala


Wednesday, October 31st 2018

Session 4: GPCRs and Physiology

Chair : Claire Gaveriaux-Ruff

9:00               Madan Babu (MRC Cambridge, UK)
Pharmacogenomics of G-protein coupled receptor drug targets

9:50               Julie Dam (Institut Cochin, Paris, France)
The orphan GPCR GPR50 and its involvement in the development of obesity/type2 diabetes 

10:15             David De Sa Nogueira (LNCA, Strasbourg, France)
Cannabinoid receptors are regulated by cocaine or sucrose in brain reward regions

10:30             Coffee break

11:00             Christoph Stein  (University of Berlin, Germany)
Opioid receptor-ligand interactions in inflamed tissue

11:50             François Dupuis (EA 3452 CITHEFOR, Nancy, France)
S-Nitrosation regulates Angiotensin II-dependent and -independent AT1 responses in the cerebral circulation

12:15             Awards & Conclusions

12:45             End of the meeting

Download this file (Programme_GDR3545.pdf)Programme_GDR3545.pdf[ ]2905 kB