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7th Annual Meeting of GDR3545, GPCR-Physio-Med in Strasbourg

Post on 23 April 2018
7th annual meeting of GDR3545 about GPCRs will take place in Strasbourg, october 29 - 31th, 2018
GPCR meeting in Strasbourg, october 2018

Download the preliminary programme : Programme of the 7th Annual Meeting of GDR3545

Deadline for abstract submission and registration : September 25th, 2018 

Venue and Access : Link

Scientific programme

6th GDR3545 workshop for Young researchers sponsored by the Dr. Antoni Esteve Foundation  October 28th (afternoon) to 29th (morning):  
Drug discovery of GPCR : scientific and career points of view in biotech and academia

Monday, October 29th 2018

12h00            Registration

14:15             Opening

Session 1: GPCRs and biased signalling

Chairs : Dominique Bonnet and Jean-Luc Galzi

14:30             Kjell Fuxe (Karolinska Institute, Sweden)
Allosteric receptor-receptor interactions in GPCR heteroreceptor complexes alter receptor protomer function. Focus on A2AR-D2R heteroreceptor complexes and cocaine addiction

15:20             Luc Maroteaux (Institut du Fer à Moulin, Paris, France)
Dimers among serotonin receptors: impact on ligand affinity and signaling

15:45             Franck Vandermoere (IGF, Montpellier, France)
Crosstalk by phospohorylation between 5HT2A and mGlU2 receptors, two important targets for antipsychotics

16:10             Alan Hégron (Institut Cochin, Paris, France) 
Identification of key regions mediating human melatonin MT1 receptor biased signaling revealed by natural variants

16:25             Francesco De Pascali (INRA, Nouzilly, France)
Biasing FSHR signaling by low molecular weight allosteric ligands

16: 40           Industrial sponsors pitches session

16:55            Coffee break

17:30            Stephan Schann (Domain Therapeutics, Illkirch, France)
Discovery of Foliglurax, an mGluR4 PAM for the Treatment of Parkinson’s Disease

18:20             Véronique Pons (I2MC, Toulouse, France)
P2Y12 receptor constitutive activity as a new target for antiplatelt therapy

18:45             Kleouforo Paul Dembele (IRIB, Rouen, France)
Analysis of G protein expression level and functions in glioma development

19:00             Thibaut Laboute (INRA, Nouzilly, France)
The orphan GPR88 receptor biases opioid receptors and other GPCR signaling through sequestration of b-arrestin

19:15             Jianfeng Liu (Huazhong University, Wuhan, Hubei, China)
GABA receptor signaling and Aging

19:30             Flash posters session 1


                        Xiaojing Cong (Université Côte d’Azur , Nice, France)
P05: Mechanism of GPCR activation triggered by ligands, mutations and protonation

                        Daniele Di Marino (Università della Svizzera Italiana, Lugano, Switzerland)
P09: A Comprehensive Description of the Homo and Heterodimerization Mechanism of the Chemokine Receptors CCR5 and CXCR4

                        Fabien Hanser (Université de Strasbourg, France)
P17: Non-Peptidic Fluorescent Turn-on Probes for Live-Cell Imaging of GPCRs

Marie-Lise Jobin (University of Würzburg, Germany)
P23: Spatial organization and dynamics of GABAB receptors as revealed by single-molecule microscopy

Kerstin Seier (University of Würzburg, Germany)
P39: Investigation of mu opioid receptor dimerization with new fluorescent ligands


19:45             Poster session (odd numbers) & Buffet


Tuesday, October 30th 2018

Session 2: GPCRs and dynamics

Chair : Didier Rognan

9:00               Laura Heitman (Leiden University, Netherlands)
Drug-target binding kinetics – a case for GPCRs

9:45               Nicolas Floquet (IBMM, Montpellier, France)
Coarse-grained simulations to predict the dynamical interactions of GPCRs with their favorite partners at the molecular level

10:15             Industrial sponsors pitches session

10:30             Coffee break

11:00             Vladimir Katanaev (University of Lausanne, Switzerland)
High capacity in G protein-coupled receptor signaling: application of information theory to signaling in health and disease

11:45             Marie Chabbert (Laboratoire MITOVASC, Angers, France)
Mutations in the sodium binding site played a key role in the evolution of chemokines receptors

12:10             Patricia Pacios Centeno (University of Manchester, UK)
Phosphate sensed by the Calcium-Sensing Receptor and its contribution to the Secondary Hyperparathyroidism of Chronic Kidney Disease

12:25             Photo & Lunch

Session 3: GPCRs, compartmentalization & signalling

Chairs : Dominique Massotte and Katia Befort

14:30             Davide Calebiro (University of Birmingham/University of Würzburg)
Shedding new light on the nanoscale organization of GPCR signalling

15:20             Guillaume Lebon (IGF, Montpellier, France)
Structural and molecular basis of Class C GCPR signalling

15:45            Claudia Desole (Université Paris Descartes, Paris, France)
Design, synthesis, pharmacological evaluation and molecular modeling of new potential antagonists targeting group III mGluRs

16:00             Alexandre Mutel (IRIB, Rouen, France)
GPCR’s activity is controlled by Filamin A in glioblastoma

16:15             Coffee break

17:00             Mario Mellado (National Center for Biotechnology, Madrid)
Modulating chemokine receptor clustering, signaling and cell responses

17:50             Anne Brelot (Institut Pasteur, Paris, France)
CCR5 adopts three homodimeric conformations that control cell surface delivery

18:15             Stefano Marullo (Institut Cochin, Paris, France)
Sialic acid-mediated mechanical activation of β2-adrenergic receptors by bacterial pilins

18:40             Lucie Hartmann (IMPReSs platform, Strasbourg, France)
Production of Antibodies Against Model G Protein Coupled Receptors Using Recombinant Semliki Forest Virus Particles as Immunogens

18:55             19:30      Flash posters session 2


                        Chayma El Khamlichi (Université d’Orléans, Orléans, France)
P10: Identification of biased ligands of 5-HT7 receptor: Molecular bases of their action

Nicolas Kahale (Université Paris Sud, Paris, France)
P18: TGR5-mediated signaling in the regulation of biliary epithelium permeability

                        Sridevi M Ramanoudjame (Université de Strasbourg, France)
P24: Fluorocarbon-peptide conjugates (FPC): new concept to increase the metabolic stability of peptides for therapeutic applications.

Steve Reynaud (Université Paris Sud, Paris, France)
P26: The first animal toxins targeting MC4R, a GPCR that controls your hunger

Maria Ricart-Ortega (IGF, Montpellier, France)
P30: Evaluating the influence of applied light on trans and cis alloswitch-1 binding to the metabotropic glutamate receptor mGlu5

19:10             General assembly animated by Ralf Jockers

19:40             Poster session (even numbers) & Gala


Wednesday, October 31st 2018

Session 4: GPCRs and Physiology

Chair : Claire Gaveriaux-Ruff

9:00               Madan Babu (MRC Cambridge, UK)
Pharmacogenomics of G-protein coupled receptor drug targets

9:50               Julie Dam (Institut Cochin, Paris, France)
The orphan GPCR GPR50 and its involvement in the development of obesity/type2 diabetes 

10:15             David De Sa Nogueira (LNCA, Strasbourg, France)
Cannabinoid receptors are regulated by cocaine or sucrose in brain reward regions

10:30             Coffee break

11:00             Christoph Stein  (University of Berlin, Germany)
Opioid receptor-ligand interactions in inflamed tissue

11:50             François Dupuis (EA 3452 CITHEFOR, Nancy, France)
S-Nitrosation regulates Angiotensin II-dependent and -independent AT1 responses in the cerebral circulation

12:15             Awards & Conclusions

12:45             End of the meeting

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