Thesis fellowship in the laboratory of "Physiologie de la Reproduction et des Comportements" UMR7247, équipe "Biologie Bioinformatique des Systèmes de Signalisation" http://bios.tours.inra.fr/bios_group/?page=sommaire
Topic: Intracellular antibodies to explore the relationships between conformations and activity of the FSH receptor, and applications in reverse pharmacology.
For more information, please see the attached file.
The five years FAPESP thematic project: Decoding molecular and cellular aspects of Plasmodium as a tool for the development of new antimalarials has opened a postdoctoral two years of position research.
The development of the project will be in collaboration with the laboratory of Molecular Signaling on Host-pathogen interactions at the Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil (https://www.topuniversities.com/universities/universidade-de-sao-paulo).
Our primary focus of interest is to elucidate how malaria parasites signal in the various stages of their life cycle in efforts to explore new venues for clinical intervention. To achieve this goal, we combine work on live cell microscopy with state-of-the-art molecular techniques. For more information see http://www.usp.br/garciamalarialab/.
The candidate should work independently, be motivated and have a Post Doctorate in the last five years in areas related to the project. The ideal candidate should have experience in biochemistry, molecular and cell biology. The project aims to unravel the function of GPCR (G protein-coupled receptors) -like proteins in the human malaria parasite P. falciparum.
Salary R$ R$ 7.373,10/month (U$ 1.886). The fellowship includes a stipend for traveling abroad/in Brazil to present the work at scientific meetings.
Part of the project could de be developed in a laboratory abroad (up to 1 year) upon application of a FAPESP-BEPE fellowship
FAPESP will fund the project according to its regulation.
Additional information in living cost in São Paulo:
Flat rental (2 bedrooms) in São Paulo R$ 1.400,00 (U$ 360) around the area of the University of São Paulo.
Two postodctoral positions are available on "Cytoskeleton and membrane-cytoskeleton interaction" in the laboratory of Pr Roberto Dominguez at the University of Pennsylvania Perelman school of medecine, Philadelphia. See attached file for further informations.
InterAx Biotech comppany is offering a position for a Scientist in Discovery & Pharmacology responsible of the assay development and drug screening. For more details see attached file.
University of Birmingham
College of Medical and Dental Sciences
Institute of Metabolism and Systems Research
Post Title: Research Fellow – Research Fellow (Postdoc) on single-molecule pharmacology of G protein-coupled receptors – 80206
Duration: Full Time, Fixed Term for 3 years
Salary: 7, Full time starting salary is normally in the range £30,395 to £39,609. With potential progression once in post to £42,036 a year.
Location: University of Birmingham, Edgbaston, Birmingham, UK
Summary of Role
Our group investigates the molecular mechanisms of signalling by G protein-coupled receptors (GPCRs), which mediate the effects of many hormones and neurotransmitters and are major drug targets. To this end, we develop innovative biophysical methods based on single-molecule microscopy and FRET (e.g. Calebiro et al. PNAS 2013; Godbole et al. Nat. Commun. 2017; Sungkaworn et al. Nature 2017). The successful applicant will utilize and further develop innovative biophysical methods based on single-molecule microscopy and advanced computational algorithms to analyse the composition and dynamics of receptor signalling nanodomains in living cells. This approach will be used to clarify some of the most crucial mechanisms involved in adrenergic receptor signalling in cardiomyocytes under normal and pathological conditions, with the ultimate goal of developing novel therapeutic strategies for cardiovascular and endocrine diseases. The project will involve designing and carrying out single-molecule microscopy experiments in living cells as well as with purified proteins to investigate the dynamic interactions among receptors, G proteins and beta-arrestins that are at the basis of GPCR signalling.
Key Responsibilities Involved
• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Disseminate research findings for publication, research seminars, etc.
• Contribute to developing new models, techniques and methods
• Contribute to Departmental/School research-related activities
• Collect research data
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines
• Completed or about to complete a PhD in biophysics, receptor pharmacology or related area
• Solid background in single-molecule imaging or similar advanced microscopy methods
• Ideally, previous experience with image analysis (e.g. single-particle tracking), programming and/or the design of optical setups
• Enthusiasm for interdisciplinary experimental research
Closing Date: 19/11/2018
To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from www.hr.bham.ac.uk
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