Post-doctoral position in the modulation of GPCR phramacology with nanobodies Physiology of Reproduction and Behaviours Unit, Nouzilly, France.
The project in which the post-doctoral fellow will be involved is based on the discovery, characterization and optimization of nanobodies capable of selectively modulating the activity of GPCRs controlling follicular development, steroidogenesis and ovulation.
Qualifications: The post-doctoral fellow will have to perform: i) pharmacological profiling and trafficking measurements using HTRF and BRET methods; ii) phage-display; iii) production, purification and characterization of recombinant proteins; iv) kinetic-rate constants determination; v) flow cytometry; vi) ELISA/HTRF assays; vi) histology/immunohistochemistry. The successful candidate will have prior experience in several of these approaches. He/she must have worked and/or have solid knowledge in biochemistry, cell biology, molecular pharmacology. Experience/knowledge in reproductive biology, antibody development/engineering, GPCR pharmacology and/or in vivo testing/phenotyping will also be appreciated. We seek for a highly motivated candidate capable of working both independently and as part of a team; endowed of excellent problem solving, organizational and communication skills. Prior international experience will be considered as an asset.
Lab website: http://bios.tours.inra.fr/