Job opportunities

Postdoctoral positions at the University of Pennsylvania, Philadelphia

on 06 February 2019

Two postodctoral positions are available on "Cytoskeleton and membrane-cytoskeleton interaction" in the laboratory of Pr Roberto Dominguez at the University of Pennsylvania Perelman school of medecine, Philadelphia. See attached file for further informations.


Scientist in Discovery & Pharmacology at INTERAX

on 10 January 2019

InterAx Biotech comppany is offering a position for a Scientist in Discovery & Pharmacology responsible of the assay development and drug screening. For more details see attached file.

Download this file (190109_InterAx_Scientist[2].pdf)190109_InterAx_Scientist[2].pdf[ ]127 kB

Research Fellow (Postdoc) on single-molecule pharmacology of G protein-coupled receptors

on 28 October 2018

University of Birmingham

College of Medical and Dental Sciences
Institute of Metabolism and Systems Research
Post Title: Research Fellow – Research Fellow (Postdoc) on single-molecule pharmacology of G protein-coupled receptors – 80206

Duration: Full Time, Fixed Term for 3 years
Salary: 7, Full time starting salary is normally in the range £30,395 to £39,609. With potential progression once in post to £42,036 a year.
Location: University of Birmingham, Edgbaston, Birmingham, UK

Summary of Role
Our group investigates the molecular mechanisms of signalling by G protein-coupled receptors (GPCRs), which mediate the effects of many hormones and neurotransmitters and are major drug targets. To this end, we develop innovative biophysical methods based on single-molecule microscopy and FRET (e.g. Calebiro et al. PNAS 2013; Godbole et al. Nat. Commun. 2017; Sungkaworn et al. Nature 2017). The successful applicant will utilize and further develop innovative biophysical methods based on single-molecule microscopy and advanced computational algorithms to analyse the composition and dynamics of receptor signalling nanodomains in living cells. This approach will be used to clarify some of the most crucial mechanisms involved in adrenergic receptor signalling in cardiomyocytes under normal and pathological conditions, with the ultimate goal of developing novel therapeutic strategies for cardiovascular and endocrine diseases. The project will involve designing and carrying out single-molecule microscopy experiments in living cells as well as with purified proteins to investigate the dynamic interactions among receptors, G proteins and beta-arrestins that are at the basis of GPCR signalling.

Key Responsibilities Involved
• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Disseminate research findings for publication, research seminars, etc.
• Contribute to developing new models, techniques and methods
• Contribute to Departmental/School research-related activities
• Collect research data
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines

Person Specification
• Completed or about to complete a PhD in biophysics, receptor pharmacology or related area
• Solid background in single-molecule imaging or similar advanced microscopy methods
• Ideally, previous experience with image analysis (e.g. single-particle tracking), programming and/or the design of optical setups
• Enthusiasm for interdisciplinary experimental research

Informal queries can be made to Davide Calebiro, This email address is being protected from spambots. You need JavaScript enabled to view it.

Closing Date: 19/11/2018
Reference No:80206

To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from
Valuing excellence; sustaining investment

Post-Doctoral Positions in Structural and Signaling Mechanisms of GPCRs, University of Pittsburgh

on 07 May 2018

Post-doctoral positions are available at the Laboratory for GPCR BiologyDepartment of Pharmacology & Chemical BiologyUniversity of Pittsburgh, School of Medicine

The Laboratory for GPCR Biology located at the Department of Pharmacology & Chemical Biology and funded by the NIH is seeking two candidates for post-doctoral fellowship positions to determine signaling mechanisms underlying the function of PTH-receptor and other GPCRs at theatomic/molecular level using Protein Biochemistry, Mass Spectrometry, X-ray Crystallography, NMR and/or Single Molecule approaches (position #1), and cellular level using TIRF/confocal/epifluorescence microscopy (position #2). The information obtained through this research will advance the development of new therapeutics for bone and mineral diseases, including medications for osteoporosis and hypocalcemia.

Preference will be given to PhD or MD/PhD applicants with a solid experience in Biochemistry, Structural Biology or Cell Biology using FRET/BRET, and with at least 2 first-authored articles published in international journals.

The University of Pittsburgh is an Equal Opportunity/Affirmative Action Employers with strong institutional commitments to diversity. Women and minority candidates are particularly encouraged to apply.

Send CV and letter of motivation to J-P. Vilardaga (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Post-doctoral position in molecular modeling IRIC Montreal

on 30 March 2018

Post-doctoral position in molecular modeling

Institute for research in immunology and cancer

Medicinal chemistry core facility

Status: Full-time

Salary: To be determined – Subject to the minimum and maximum set out by the collective agreement

Start date: Spring 2018

Estimated end date: 1 year, renewable

The medicinal chemistry platform at the Institute for Research in Immunology and Cancer (IRIC) at the University of Montréal has an opening for a postdoctoral position in molecular modeling in the field of drug discovery.
Under the supervision of Dr. Anne Marinier and Dr. Alexandre Beautrait, the incumbent will conduct computer-aided modeling work that support ongoing projects across various therapeutic areas (academic and industrial collaborations). As part of a multi-disciplinary team of medicinal chemists and biologists the incumbent will apply computational chemistry techniques (both ligand and structure-based) to support lead-identification and lead-optimization endeavors taking place at the medicinal chemistry platform.

Interested candidates should submit a full CV, a one-page statement of research interests, and electronic copies of up to three recent publications in a single PDF attachment to the email address: This email address is being protected from spambots. You need JavaScript enabled to view it.